肝再生与胆汁酸代谢

Liver regeneration and bile acids metabolism

近年来研究发现肝再生和胆汁酸密切相关.肝再生时胆汁分泌状态、胆汁酸合成限速酶、胆汁酸成分以及转运蛋白均发生变化,以避免胆汁酸对肝细胞的毒性作用.体内外实验表明,胆汁酸可促进肝细胞增生,肝再生可能与胆汁酸失衡后所释放的信号有关.因此,研究肝再生和胆汁酸代谢的相互关系,对提高肝脏再生能力有着重要的现实意义.

The liver regeneration is closely related to the bile acids. To avoid the toxic effects of bile acids on hepatocyte, the state of bile secretion, the rate-limiting enzyme of the bile acid synthesis, bile acids composition as well as the transporter changes at the process of liver regeneration. In vivo and in vitro experiments show that bile acids can promote liver cell proliferation, liver regeneration may be related to the signal which is released under the bile acid imbalance. The relationship between the liver regeneration and bile acid metabolism has an important practical significance in liver regeneration.