聚焦超声治疗肝细胞肝癌的免疫学机制及进展

Development of immunology on HIFU in hepatocarcainoma

肝癌是目前世界上常见的恶性肿瘤之一,据我国卫生部1995年统计资料显示,肝癌年死亡率为0.02%,居第二位,且有上升趋势.手术治疗一直是肝癌综合治疗的主要手段.近10余年来,随着超声学治疗学的飞速发展,新兴起的高强度聚焦超声（HIFU）作为一种无创性非手术疗法,利用瞬态高温、空化和机械效应杀死肿瘤细胞的新手段越来越引起重视,并在实验研究和临床应用方面取得了一定进展.有文献显示,HIFU治疗肝癌可改善机体的免疫紊乱状态,促进局部组织中的细胞免疫反应.本文将对聚焦超声在肝细胞肝癌的免疫治疗中的机制及免疫学进展进行阐述.

Hepatocellular carcinoma（HCC） is one of the most common malignant tumors in the world.According to the statistic data of Ministry of Public Health of China in 1995, the annual mortality of HCC was 20.4 per 0.1 million, and had the rise tendency. Surgery is commonly the main modality of HCC combined therapy. The high intensity focused ultrasound （HIFU）, as a noninvasive therapy, with the mechanism of transient high temperatures, cavitation and mechanical effects, has been recognized. This review aimes to elucidate the immune changes in HCC after HIFU exposures and the mechanism.