自杀基因旁观者效应的研究进展

Current progress in bystander effect of suicide gene therapy

目前世界上威胁人类健康常见的疾病之一仍然是肿瘤,人类针对肿瘤进行着孜孜不倦的研究,目前在肿瘤治疗方面,基因治疗是一个较为有前途的治疗手段,其中肿瘤自杀基因疗法是研究最为广泛的,而旁观者效应在肿瘤自杀基因疗法中起着相当重要的作用,因此,为提高自杀基因杀伤肿瘤效果,部分研究者从增强旁观者效应方面做了许多研究.故本文从增强自杀基因旁观者效应治疗肿瘤方面做一综述.

Nowadays, tumor is one of the most challenging human health diseases, which oblige human tirelessly to studied for the tumor.Gene therapy is a promising treatment in oncotherapies. Suicide gene therapy is the most widely researched among gene therapies. At the same time, bystander effect take important role in the mechanism of suicide gene therapy. Therefore, more researchers devote themselves to studyinghow enhance the bystander effect in order to improve the effect of suicide gene therapy. This article reviewed in short how to augment bystander effect of suicide gene therapy against cancer.