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慢性丙型肝炎患者合并肝外自身免疫现象及自身抗体分析在与自身免疫性肝炎鉴别诊断中的意义 被引量:10

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摘要 目的探讨慢性丙型肝炎与自身抗体及自身免疫病的关系以及与临床特征的相关性。方法采用荧光定量聚合酶链反应和聚合酶链反应-微板核酸杂交-ELASA法及间接免疫荧光法对467例慢性丙型肝炎HBV、HCV定性、定量以及抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗肝肾微粒体抗体(LKMA1)、抗线粒体抗体(AMA)、甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)分析,并比较其与相应人群自身抗体的发生率。结果 467例慢性丙型肝炎患者中单纯合并自身抗体者152例(32.55%)。并发自身免疫病者26例(5.57%)。330例慢性乙型肝炎单纯合并自身抗体者29例(8.79%),未见合并自身免疫病表现者。慢性丙型肝炎患者是否合并自身免疫现象与性别、年龄以及病程均无明显关系,但合并自身免疫现象者血清ALT及TBIL水平高于不合并自身免疫现象者(P<0.05)。GGT与ALB在两组间无显著差别。慢性丙型肝炎合并自身免疫现象者与自身免疫性肝炎者ANA、SMA和LKMA1的阳性率比较无显著性差异,而TMA、TGA则主要见于合并自身免疫现象的慢性丙型肝炎患者。AMA在两组中均未检出。结果表明自身免疫性肝炎患者血清ANA、SMA和LKMA1自身抗体水平明显高于丙型肝炎合并自身免疫现象者,两者比较显著差异(P<0.05)。结论慢性丙型肝炎患者易并发自身免疫现象,慢性丙型肝炎合并自身免疫现象者自身抗体发生率高,且病情相对较重。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第15期2097-2099,共3页 Chinese Journal of Gerontology
基金 长春市科技局项目(05SF311)
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参考文献10

  • 1Cacoub P,Renou C,Rosenthal E,et al.Extrahepatic manifestations associated with hepatitis C virus infection:a prospective multi-center study of 321 patients[J].Medicine (Baltimore),2000;79:47-56.
  • 2Tomer Y.Hepatitis C and interferon induced thyroiditis[J].J Autoimmun,2010;34(3):J322-6.
  • 3Buskila D.Hepatitis C-associated rheumatic disorders[J].Rheum Dis Clin North Am,2009;35(1):111-23.
  • 4Mayo MJ.Extrahepatic manifestations of hepatitis C infection[J].Am J Med Sci,2002;325:135-48.
  • 5Agnello V,De Rosa FG.Extrahepatic disease manifestations of HCV infection:some current issues[J].J Hepatol,2004;40:341-52.
  • 6丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:735
  • 7Mouelhi L,Debbeche R,Sfar I,et al.Auto-immune serological disorders in chronic viral C hepatitis:prevalence and clinical significance[J].Tunis Med,2008;86(9):777-81.
  • 8EL-Serag HB,Hampel H,Yeh C.Extrahepatic manifestations of hepatitis C among United States male veterans[J].Hepatology,2002;36:1439-45.
  • 9De Riva V,Celadin M,Pittoni M,et al.What is behind the presence of anti-neutrophil cytoplasmatic antibodies in chronic liver disease[J]?Liver Int,2009;29(6):865-70.
  • 10Antonelli A,Ferri C,Ferrari SM,et al.Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia[J].Autoimmun Rev,2008;8(1):18-23.

二级参考文献15

  • 1Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non- responders to interferon monotherapy: a meta- analysis of individual patient data[ J ]. Gut, 2002,51:864-869.
  • 2Papatheodoridis GV, Papadimitropoulos VC, Hsdziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus- reated cirrhosis: a meta- analysis[J] .Aliment Pnarmaool Ther, 2001,15:689- 698.
  • 3Kjaergard LL, Krogsgaard K, Gluud C. Interfern alfa with or without ribavirin for chronic hepatitis C: systematic review of randonmised trials[J].BMJ, 2001,323:1151 - 1155.
  • 4Alberti A, Benvegnu L. Management of hepatitis[J] .J Hepatol, 2003,38(Suppl1): S1014 - S1 18.
  • 5Poynard T, MdHutchison J, Davis GL, et al. Impact of interferon alfa - 2b and ribavirin on progression of liver fibrosiis in patients with chronic hepatitis C[J].Hepatology, 2000,32:1131 - 1137.
  • 6Booth JCL, O' Grady J, Neuberger J. Clinical guidelines on the mangement of hepatitis C[J]. Gut, 2001, 49(Suppl I ): il - i12.
  • 7Chander G, Sulkowski MS, Jenckes MW, et al. Treatment of chronic hepatitis C: a systemic review[J]. Hepatology, 2002, 36(5 Suppl 1 ):S135 - S144.
  • 8Di Ciomm no V, Russo P, Rava L, etal. Interferon alpha in the treatment of chronic hepatitis C in children: a mmeta- analysis[J] .J Viral Hepat,2003,10:210 - 214.
  • 9Fabrizi F, Dulai G, DixitV, et al. Meta- analysis: interfeorn for the treatment of chronic hepatitis C in dialysis patients[J] .Aliment Phamacol Ther, 2003,18:1071 - 1081.
  • 10National Institute of Health Consensus Development Conference Panel Statenent. Management of hepatitis C[J].Hepatology, 2002,36(5 Suppl 1):S3- S20.

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