复方七芍降压片对自发性高血压大鼠血压及血液流变学的影响

Effect of Fufang Qishao Jiangyapian on Blood Pressure and Hemorrhelogy of Spontaneously Hypertensive Rats

目的观察复方七芍降压片对自发性高血压大鼠(SHR)的降压作用及其对血液流变学的影响。方法以12只8周龄Wistar-kyoto(WKY)大鼠为正常组,48只8周龄自发性高血压大鼠随机分为4组:模型组、卡托普利组[6.75mg/(kg.d)]及复方七芍降压片低[0.9mg/(kg.d)]、高[3.6mg/(kg.d)剂量组,连续灌胃4周,观察其血压及血液流变学变化。结果与正常组比较,SHR全血粘度、血浆粘度、血浆纤维蛋白含量及红细胞压积均明显升高(P<0.01);复方七芍降压片治疗后,血压及血液流变学各指标均明显下降(P<0.01)。结论复方七芍降压片对SHR有明显的降压作用,其机制可能与其改善血液流变学指标有关。

Objective To explore the mechanism of Fufang Qishao Jiangyapian on lowering bloodpressure and hemorheology of spontaneously hypertensive rats （SHR）. Method 8-week-old normal Wistar-Kyoto （WKY） rats were used as normal group and 48 8-week-old spontaneously hypertensive rats（SHR） were divided into 4 groups at random：model group, captopril group [6.75 mg/（kg·d）], lowdose[0.9 mg/（kg·d）] and high-dose [3.6 mg/（kg·d）] Fufang Qishao jiangyapian group. 4 weeks later, thechanges of blood pressure and hemorheology were observed. Results Compared with the normal group, thewhole blood viscosity, plasma viscosity, plasma fibrin and hematocrit of SHR sharply rose （P 〈0.01）. Afterthe treatment of Fufang Qishao Jiangyapian, blood pressure and hemorrheology parameters weredecreased （P 〈0.01）. Conclusion Fufang Qishao Jiangyapian can lower the blood pressure of SHR, itsmechanism may be related to improving hemorrhelogy.