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糖尿病心肌病与过氧化物增殖体激活受体 被引量：7

Relationship between diabetic cardiomyopathy and peroxisome proliferators-activated receptors
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摘要 糖尿病心肌病(DC)是糖尿病的独立并发症,发病过程中心肌出现脂肪酸氧化利用升高和葡萄糖利用率下降等能量代谢紊乱,严重影响DC心脏功能和结构。过氧化物增殖体激活受体(PPARs)属于核受体超家族成员,是机体糖、脂肪酸代谢途径的关键调节基因,在DC心脏能量调节中起重要作用,直接或间接干预DC状态下心脏功能变化。 Diabetic cardiomyopathy （ DC） is an independent complication of diabetes mellitus accompanied with cardiac metabolic imbalances （ increase of fatty acids and reduction of glucose） ,which would impair cardiac function and structure seriously. Peroxisome proliferator-activated receptors （ PPARs） are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily,and they could transcriptionally regulate energy metabolism and function. PPARs also play an important role in regulating metabolism in DC heart,and directly or indirectly affect cardiac function and structure.
作者 董世芬 洪缨 孙建宁
机构地区 北京中医药大学中药学院中药药理系
出处 《中国药理学通报》 CAS CSCD 北大核心 2010年第8期1117-1120,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30840103) 北京市中药基础与新药研究重点实验室研究专项
关键词 糖尿病心肌病 过氧化物增殖体激活受体 脂肪酸代谢 糖代谢 心脏功能 心脏结构 diabetic cardiomyopathy peroxisome proliferator-activated receptors fatty acid metabolism glucose metabolism cardiac function cardiac structure
分类号 R-05 [医药卫生] R322.11 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

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二级参考文献6

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共引文献4

同被引文献49

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引证文献7

二级引证文献32

中国药理学通报
2010年 第8期

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