3SAMUEL C S,HEWITSON T D,UNEMORI E N.Drugs of the future:the hormone relaxin[J].Cell Mol Life Sci,2007,64(12):1539-1557.
4SAMUEL C S,LEKGABE E D,MOOKERJEE I.The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease[J].Adv Exp Med Biol,2007,612:88-103.
5UNEMORI E N,AMENTO E P.Rclaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts[J].J Biol Chem,1990,265(18):10681-10685.
6SAMUEL C S,ZHAO C,BATHGATE R A.Relaxin deficiency in mice is associated with an age-relatod progression of pulmonary fibrosis[J].Faseb J,2003,(17):121-123.
7GARBER S L,MIROCHNIK Y,BRECKLIN C S.Relaxin decreases renal interstitial fibrosis and slows progression of renal disease[J].Kidney Int,2001,59(3):876-882.
8HEWITSON T D,MOOKERJEE I,MASTERSON R.Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis[J] Endocrinology,2007,148(2):660-669.
9DANIELSON L A,WELFORD A,HARRIS A.Relaxin improves renal function and histology in aging Munich Wistar rats[J].J Am Soc Nephrol,2006,17(5):1325-1333.
10MOOKERJEE I,HEWITSON T D,HALLS M L.Relaxin inhibits renal myofibroblast differentiation via RXFPI,the nitric oxide pathway and Smad2[J].Faseb J,2009,23(4):1219-1229.
2SAMUEL C S.Relaxin:antifibrotic properties and effects in models of disease[J].Clin Med Res,2005,3(4):241-249.
3SAMUEL C S,ZHAO C,BOND C P,et al.Relaxin-1-deficient mice develop an age-related progression of renal fibrosis[J].Kidney Int,2004,65(6):2054-2064.
4LEE W J,CHOI I K,LEE J H,et al.Relaxin-expressing adenovirus decreases collagen synthesis and up-regulates matrix metalloproteinase expression in keloid fibroblasts:in vitro experiments[J].Plast Reconstr Surg,2012,130(3):407e-417e.
5LI X F,LIAO J,XIN Z Q,et al.Relaxin attenuates silica-induced pulmonary fibrosis by regulating collagen type I and MMP-2[J].Int Immunopharmacol,2013,17(3):537-542.
6HUANG X,GAI Y,YANG N,et al.Relaxin regulates myofibroblast contractility and protects against lung fibrosis[J].Am J Pathol,2011,179(6):2751-2765.
7DU X J,SAMUEL C S,GAO X M,et al.Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice:a genderspecific phenotype[J].Cardiovasc Res,2003,57(2):395-404.
8KAMAT A A,FENG S,BOGATCHEVA N V,et al.Genetic targeting of relaxin and insulin-like factor 3 receptors in mice[J].Endocrinology,2004,145(10):4712-4720.
9SAMUEL C S,ZHAO C,BATHGATE R A,et al.Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis[J].FASEB J,2003,17(1):121-123.
10LIU C,ERISTE E,SUTTON S,et al.Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135[J].J Biol Chem,2003,278(50):50754-50764.
