痰液降钙素原测定在婴幼儿喘息中的应用

Application of the sputum procalcitonin detection in wheezing infants

【目的】探讨痰液降钙素原（procalcitonin,PCT）测定在婴幼儿喘息中指导抗生素使用的价值。【方法】用一次性吸痰管吸取深部痰液,采用免疫色谱法测定PCT。【结果】痰细菌培养阳性者痰PCT阳性率88.4%,痰培养阴性者痰液PCT阳性率仅14.0%,差异有统计学意义（P=0.000）;痰细菌培养阳性者于抗生素治疗3~5 d复查痰液PCT仍有53.5%阳性,明显高于血清PCT和痰培养（P〈0.05）,临床症状、体征消除后复查各指标均恢复正常。【结论】痰液PCT检测值高于血清PCT检测和细菌培养,可以作为协助判断喘息患儿细菌感染的指标,减少抗生素的不合理使用。

【Objective】 To study the clinical value of the sputum procalcitonin detection in wheezing infants for guidirg the use of antibiotics. 【Method】 PCT levels were measured by using immune chromatography in sputum sampled through disposable suction tube. 【Results】 Patients with sputum bacterial culture positive were 88.4% positive in PCT,while patients with sputum bacterial culture negative was only 14.0% positive in PCT,the difference was significant（P=0.000）.After 3 to 5 days of antibiotic treatment in patients with sputum bacterial culture positive,when symptoms and signs became normal,53.5% patients were still sputum PCT positive,significantly higher than that of serum PCT and sputum culture（P0.05）. 【Conclusion】 Sputum PCT is higher than serum PCT and bacterial culture,which can be used as an indicator of bacterial infection in wheezing infants and irrational use of antibiotics could be reduced.