基于相位同步分析方法的抑郁症脑电信号的研究

Quantitative Analysis of Electroencephalograph in Depression Based on Phase Synchronization

介绍使用相位同步分析方法对抑郁症患者和正常对照组在闭眼和心算两种状态下的脑电信号进行研究。相对于传统的定量脑电信号分析方法,相位同步分析法只考察信号间的相位关系,而摒弃了信号间的幅度的影响,可以检测出信号间微弱的相互作用关系。研究表明,抑郁症组在闭眼和心算时全局相位同步指数显著低于正常组,其中左半球和半球之间相同步指数与正常组相比都存在显著性差异,而右半球相同步指数则无明显差异。

EEG signals of depression patients and normal control subjects under the states of closed eyes and mental arithmetic are investigated through the method of phase synchronization（PS）analysis.Compared with conventional quantitative EEG（qEEG）analysis,PS analysis is a powerful method which can detect the weak interaction between signals by quantifying the relationship of the instantaneous phases of the signals but excluding the influence of the amplitudes.Results suggest that the global PS index of depression in the two states are much lower than that of controls,and the left hemispheric and the inter-hemispheric PS indices of depression show significant difference from that of controls,while the right hemispheric PS index shows no significant difference between these two groups.