全身红光治疗对烧伤创面愈合的有效性和安全性评价

Efficacy and Safety Evaluation of Systemic Red Light Therapy for Burn Wound Repair

目的探讨全身红光治疗对烧伤创面修复的影响及其安全性评价。方法将深II度创面的患者138例,随机分为全身红光治疗组和常规治疗组,每组各69例。在不干扰患者正常治疗的前提下,分别给予PDT-FL-201型全身红光治疗机治疗或不采用红光治疗。1次/d,每次30分钟,连续照射直至创面完全愈合。在伤后第7、10、14、21天和痊愈当天进行临床相关指标的评价。结果应用全身红光治疗组和对照组创面平均愈合时间分别为19.86±2.43天和21.02±2.97天,两组差异有统计学意义(P<0.05)。治疗组伤后第10天、14天换药时疼痛强度均比对照组高,差异有统计学意义。结论 PDT-FL-201型吊顶式全身红光治疗机治疗以早期深二度烧伤为模型的急性创面具有促进创面愈合与缓解疼痛的作用。

Objective To investigate effects of systemic red light therapy on wound repair of burned patients and discuss its possible mechanisms of wound healing promotion.Methods 138 burnd patients were randomly divided into systemic red light treatment group（n=69）and control group（n=69）.Patients in control group received routine therapy,while those in test group were given systemic red light therapy once a day,30 minutes at a time until the wounds were recovered.The clinical findings and variables indicating wound repair were assessed on the 7th,10th,14th day,21st day post-burn and the day when the wounds were healed.Results Mean time of wound recovery were 19.86±2.43 days and 21.02±2.97days respectively of those deep-thickness wounds in test group and control group,with statistically significance（P〈0.05）.For the severity of the pain,VAS during time of dressing change on the 10th,14th day post burn was lower in test group than that in control group which indicated less painful in test group（P〈0.05）,suggesting pain relief effect of systemic red light therapy.Conclusion Systemic red light therapy was effective to promote wound healing of deep-thickness burn wounds and other similar acute wounds.Simultaneously,it is efficacious in pain relief and safe for those patients.