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IFN-γ对原代喉癌细胞增殖及血管内皮生长因子-C转录的影响

Effects of IFN-γ on primary laryngeal squamous carcinoma cell proliferation and VEGF-C gene transcription
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摘要 目的研究IFN-γ对体外培养的原代喉癌细胞的作用。方法采用MTT比色法观察IFN-γ对原代喉癌细胞生长的影响。实时PCR法观察IFN-γ对原代喉癌细胞血管内皮生长因子C(VEGF-C)基因表达的影响。结果 IFN-γ对原代喉癌细胞生长的抑制作用呈剂量依赖性;1000U/mLIFN-γ作用于原代喉癌细胞后48h后,VEGF-C基因转录水平明显下调。结论 IFN-γ抑制原代喉癌细胞的增殖,下调VEGF-C基因表达,为寻求喉癌免疫治疗提供了新途径。
作者 马韬
机构地区 黑龙江齐齐哈尔市五官医院
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2010年第4期261-262,共2页 Chinese Journal of Biochemical Pharmaceutics
关键词 IFN-Γ 原代喉癌细胞 血管内皮生长因子C
分类号 R739.6 [医药卫生—肿瘤]
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参考文献6

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二级参考文献21

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中国生化药物杂志
2010年 第4期

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