新型蛋白Nischarin的研究进展

Progress in study of a novel protein Nischarin

Nischarin是近年来在小鼠体内被发现与整合素α5亚基相互作用的一新型蛋白。研究表明,Nischarin在抑制肿瘤细胞迁移、侵袭方面发挥重要作用,还可能是天然的功能性I1-咪唑啉受体。对该蛋白的研究将有助于认识与理解抑制细胞迁移的生物学机制,开发与此蛋白相关的新型药物如肿瘤侵袭抑制剂。该文结合近年国内外关于Nischarin的研究进展做一综述。

Nischarin is a novel protein interacting with integrin α5 subunit.A series of studies have indicated that Nischarin plays an important role in inhibiting tumor cells migration and invasion.Meanwhile it may also serve as the functional I1-imidazoline receptor.To study this protein will be in favour of understanding the biological mechanisms of inhibiting cell migration and developing novel drugs such as inhibitors for tumor invasion.The article mainly reviews the recent progress in studies on Nischarin.