p53和c-erbB-2与胃癌关系的研究进展

Progress of The Relationship Between p53 and c-erbB-2 in Gastric Cancer

目的介绍近年来抑癌基因p53和癌基因c-erbB-2与胃癌关系的研究进展。方法收集近年来国内、外关于胃癌中p53和c-erbB-2的相关文献并进行综述。结果 p53基因突变和c-erbB-2的过表达是胃癌发生中的常见事件。p53突变与胃癌的发生部位及其侵袭性生物学行为有关;c-erbB-2的过表达可作为判断胃癌预后的独立参数。针对p53及c-erbB-2的基因靶向治疗药物也在不断研究中。结论深入研究p53与c-erbB-2基因在胃癌发生、发展中的作用,将有助于清楚地认识胃癌的生物学行为,并为胃癌的基因治疗提供理论依据。

Objective To explore the progress of the relationship between the tumor suppressor gene p53 and oncogene c-erbB-2 and gastric cancer in recent years. Methods Relevant literatures about p53 and c-erbB-2 in gastric cancer were collected and analyzed. Results The mutation of p53 gene and the over-expression of c-erbB-2 gene were a common event in gastric cancer. The mutation of p53 gene was correlated with the location of gastric cancer and its aggressive biological behavior. The over-expression of c-erbB-2 gene could be used as an independent prognostic parameter in gastric cancer. The drugs targeted on p53 and c-erbB-2 gene were being developed. Conclusion Further research on the role of p53 and c-erbB-2 gene in the development of gastric cancer is helpful to understand the biological behavior and provide theoretical basis for gene therapy.