度洛西汀与文拉法辛治疗躯体形式障碍的疗效比较

A comparative study of efficacy of duloxetine and venlafaxine of treating somatoform disorder

目的比较度洛西汀与文拉法辛治疗躯体形式障碍的疗效和安全性。方法将137例躯体形式障碍患者随机分为文拉法辛组69例和度洛西汀组68例,共治疗6周。采用HAMD和SCL-90评定临床疗效,TESS评定不良反应。结果在治疗第2周末文拉法辛显效率为53.62%,度洛西汀仅为29.41%,前者优于后者,差异具有极显著性(P<0.01);但在治疗第4、6周末,文拉法辛组的显效率为78.26%、85.50%,度洛西汀组的显效率为79.14%、86.71%,两组同期比较疗效无显著差异(P>0.05)。文拉法辛引起血压升高、睡眠增多、哈欠和乏力等不良反应相对突出。结论两药治疗躯体形式障碍均有效,且疗效相当,文拉法辛起效稍快,度洛西汀的不良反应相对较轻。

Objective Duloxetine is comparable with venlafaxine in the efficacy and safety of treating somatoform disorder.Methods The 137 somatoform disorder patients are divided into the two parts which are 69 venlafaxine patients and 68 duloxetine patients,treating for 6 weeks.Using the HAMD and SCL-90 evaluates the clinical curative effect,and using TESS evaluates the untoward effect.Results Behind the 2nd week,effective percentage of using venlafaxine to treat patient is 53.62%,and effective percentage of using duloxetine is 29.41%,so venlafaxine is better than duloxetine in the efficacy and safety of treating somatoform disord.The result has very most notable difference（P0.01）;but in the fourth and sixth,effective percentage of using venlafaxine is 78.26% and 85.50%,and effective percentage of using duloxetine is 79.14% and 86.71%.The result has no notable difference（P0.05）.The untoward effect which venlafaxine results in ncluding raising blood pressure,increaing sleep time,yawning,being tired and so on is very outstanding.Conclusion They are equivalent in the efficacy of treating somatoform disorder.Venlafaxine works faster and the untoward effect of duloxetine is lighter.