两种不同的方法治疗早期糖尿病肾病疗效分析

A Curative Effects of in Early Diabetic Nephropathy by Two Treatment Methods

目的探讨两种不同的方法治疗早期糖尿病肾病的临床疗效。方法 150例早期糖尿病肾病(DN)患者随机对照组75例和治疗组75例,两组患者在常规降糖药物和(或)降压药物治疗的基础上,治疗组给缬沙坦80mg/d,口服,同时给氟伐他汀40mg/d,口服;对照组给缬沙坦80mg/d,口服。两组疗程3个月。比较两组治疗前及治疗后尿白蛋白排泄率(UAER)、血肌酐(Scr)和反应蛋白(CRP)等指标。结果对照组治疗后SBP、DBP、UAER含量[(123.22±11.54)mmHg、(70.11±9.89)mmHg、(130.58±20.86)μg/min]低于治疗前[(130.22±9.21)mmHg、(76.56±8.22)mmHg、(145.78±25.44)μg/min](t=2.145,t=2.214,t=2.211,P均<0.0.5);治疗组治疗后UAER、CRP含量[(102.71±21.11)μg/min、(3.83±1.41)mg/L]明显低于治疗前[(144.44±24.12)μg/min、(7.13±1.64)mg/L](t=2.845,t=2.914,P均<0.05);治疗组治疗后UAER、CRP与对照组比较有显着性差异(t=2.014,t=2.25,P均<0.05)。结论氟伐他汀具有降低CRP的抗炎效应,与缬沙坦联用对早期糖尿病肾病进行干预治疗,可有效地降低尿清蛋白排泄率,保护肾功能。

Objective To investigate the curative effects in early diabetic nephropathy （EDN）by two treatment way. Methods 150 cases with EDN were divided into two groups, the control group（n=75） and the treated group （n=75）.Two groups were strictly enforced in the diabetic diet, low-quality protein intake, conventional hypoglycemic drug and/or blood pressure medication treatment. The therapy group was given the valsartan80mg/d,orally, at the same time to fluvastatin 40mg/d, ora; l while the control group was given the valsartan 80mg/d, ora.l Two groups were treated for 3 months. Compare the index of UAER, Scr and CRP respectively. Results The contents of SBP, DBP, UAER in control group after treatment[（123.22±11.54）mmHg、（70.11±9.89）mmHg, （130.58 ±20.86）μg/min] were signifi cantly lower than before treatment[（130.22±9.21）mmHg, （76.56±8.22）mmHg, （145.78±25.44）μg/min] （t=2.145, t=2.214, t=2.211, P al〈l0.05）;The contents of UAER, CRP in treatment group after treatment[（102.71±21.11）μg/ min, （3.83±1.41）mg/L] was signifi cantly lower than before treatment[（144.44±24.12）μg/min, （7.13±1.64）mg/L]（t=2.845, t=2.914, P all〈0.05）;The contents of UAER, CRP in treatment group compared with the control group there were signifi cant difference（t=2.014, t=2.25, P all〈0.05）.Conclusion Fluvastatin combined with valsartan as early intervention therapy on the DN can be more effective in reducing urinary album in excretion rate and protect the renal function.