两种抗早熟医院中药制剂的煎煮时间改进

Comparison of different boiling time of two anti-premature hospital Chinese medicines

目的观察本院两种抗早熟医院中药制剂不同煎煮时间对产品质量的影响,旨在进一步优化制备工艺。方法以薄层色谱鉴别、pH值、总固体和黄芩苷含量为评价指标,比较不同煎煮时间(煎煮2次或3次)制备的抗早熟医院中药制剂成分及其制剂稳定性。结果两种煎煮次数制备的抗早熟医院制剂有效成分及各项物理指标无显著差异,且初步结果提示其临床疗效也无显著影响。结论本院两种抗早熟医院制剂煎煮时间缩短为2次能达到制剂的质量要求,有关药理和临床评价尚待进一步研究。

Objective To observe the quality of two anti-premature hospital Chinese medicines by different boiling time,and to optimize the preparation process. Methods The ingredients and stability of two hospital Chinese medicines by different boiling times （2 or 3 times） were compared. The evaluating indicators included thin layer chromatography identification,pH,total solids and baicalin content. Results There was no significant difference in active ingredients and physical indexes between them and the clinical effects were similar. Conclusion The shortened boiling time（2 times）of two anti-premature hospital medicines could achieve the quality standard. The results of the pharmacological and clinical evaluation need further study.