贝那普利对糖尿病性心肌病患者C-反应蛋白的影响

The influence of benazepril on the serum C-reactive protein level in patients with diabetic cardiomyopathy

目的观察贝那普利对糖尿病性心肌病(DCM)患者血清C-反应蛋白(CRP)水平的影响。方法 72例DCM患者随机被分为贝那普利组和常规治疗组,贝那普利组在常规治疗基础上加用贝那普利治疗。采用免疫透射比浊法分别测定治疗前和6月时的CRP浓度。结果贝那普利组治疗6月后CRP浓度从(6.92±1.02)mg/L显著下降到(6.36±0.56)mg/L,P<0.01;常规治疗组6个月观察期内CRP无明显变化。结论贝那普利可以明显降低DCM患者血清CRP的浓度,减轻慢性炎性反应。

Objective To investigate the influence of Benazepril on the serum C-reactive protein （ CRP） level in patients with diabetic cardiomyopathy （ DCM）. Methods 72 patients with DCM were randomly assigned into conventional treatment group and Benazepril group. The Benazepril group was given Benazepril in addition to conventional treatment. The serum CRP level in all subjects were determined by immunonephelometry before treatment and after six month treatment. Results The serum levels of CRP in the Benazepril treatment group were significantly decreased from （ 6. 92 ± 1. 02 ） mg/L to （ 6. 36 ± 0. 56 ） mg/L after 6 months of benazepril treatment. In the conventional treatment group,the serum CRP level was unchanged 6 months following-up. Conclusion Benazepril can effectively reduce the chronic inflammation in patients with DCM.