高危型HPV感染致CIN的治疗进展

Development in treatment of CIN caused by high-risk HPV infection

宫颈癌是常见的妇科恶性肿瘤之一,导致宫颈癌的危险因素主要为持续性高危型人乳头状瘤病毒感染宫颈的移行带上皮,其机理可能是机械性原因,也可能是生物性原因.高危型人乳头状瘤病毒感染后要经过宫颈上皮内瘤变→原位癌→早期浸润癌→浸润癌这一连续缓慢的演化过程.因此,对宫颈癌前病变的早期筛查及合理干预是预防宫颈癌的重要环节.近年来,随着对宫颈癌筛查的开展和推广,临床上诊断的宫颈上皮内瘤变日益增多,因此对其诊治处理显得尤为重要.该文就根据宫颈上皮内瘤变病情选择正确和规范的治疗及监测方法 进行了探讨.

Cervical carcinoma is one of common gynecological malignancies. One of the main risk factors of cervical carcinoma is cervical epithelial cells in transitional zone being infected persitently by high-risk HPV and its mechanism may be mechanical or biological. The evolution process of cervical epithelial cells in transitional zone after being infected by high-risk HPV is a continual and slow process which would experience cervical intraepithelial neoplasia（ CIN Ⅰ →CINⅡ →CINⅢ ）-carcinoma in situ of cervix-early invasive invasive carcinoma. Therefore, early screening and reasonable intervention of cervical precancerous lesions are important steps for prevention of cervical carcinoma. In recent years, along with conduction and generalization of screening of cervical carcinoma, the detectable rate of CIN is gradually increased, so, diagnosis and treatment of CIN become very important. In this paper, we explored choices of correct and standardized treatment of CIN according to condition of the disease and its monitoring in clinic.