摘要
目的:建立大鼠高尿酸血症肾损害动物模型。方法:采用不同配比的腺嘌呤和氧嗪酸钾给实验大鼠灌胃,观测实验前后大鼠血清尿酸、肌酐、尿素氮水平变化,行肾组织病理与超微病理观察。结果:各组大鼠血尿酸均有不同程度的升高,高剂量组肾损害较重,低剂量组肾损害不明显。结论:中剂量组作为高尿酸血症动物模型较为合适。
Objective：establish animal model of hyperuricemia with nephric lesion using mice.Methods：using Adenine and oxonic acid intragastric administration to mice,investigate the alteration of rat＇s serum,including uric acid,creatinine and urea nitrogen about.Results：blood uric acid upgraded in every group,nephric lesion in group of high dosage is serious,in low dose group it has no damage.Conclusion：Middle dosage group is suitable for the animal model of hyperuricemia.
出处
《中华中医药学刊》
CAS
2010年第8期1573-1575,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30271629)
