EGFR在非小细胞肺癌患者血清中的水平及临床意义

The expression of EGFR protein in serum of non-small lung cancer patients and its clinical significance

目的探讨表皮生长因子受体(EGFR)在非小细胞肺癌患者血清中的水平及其临床意义。方法采用ELISA方法检测47例非小细胞肺癌患者(腺癌27例、鳞癌14例,腺鳞癌4例、大细胞未分化癌2例)以及20例良性肺病患者血清中EGFR的表达水平。结果 EGFR(μg/ml)在肺部良性病变、肺腺癌、肺鳞癌、肺腺鳞癌以及肺大细胞肺癌患者血清中表达水平分别为1.189±2.548、24.680±6.377、11.110±2.911、14.500±6.189及3.915±2.157,其中肺腺癌患者血清中表达水平最高(P<0.05)。另外,非小细胞肺癌患者血清中EGFR表达水平与患者的性别相关(P<0.05),而与年龄无关(P>0.05)。结论 EGFR在非小细胞肺癌血清中的表达与病理类型和性别有关,是女性腺癌患者血清中有价值的肿瘤标记物,为EGFR酪氨酸激酶抑制剂(EGFR-TKI)选择合适人群提供了实验室依据。

Objective To evaluate the expression of EGFR protein in serum of non-small lung cancer patients and its clinical significance.Methods Ezyme linked immunosorbent assay ELISA） was used to detect the the expression of EGFR protein in serum of non-small lung cancer patients and lung benign changes patients.Results The level of EGFR（μg/ml）in patients of lung benign changes,adenocarcinoma,squamous cell carcinoma,adenosquamous carcinoma and large cell lung carcinoma was 1.189±2.548,24.680±6.377,11.110±2.911,14.500± 6.189 and 3.915±2.157,respectively.The level of EGFR is related to the gender of patients（P〈0.05）,and have no correlation with the age of patients（P〉0.05）.Conclusion The EGFR expression in serum of patients of non-small lung cancer patients is related to the histological types and the gender,and can be a valuable biomarker in the selection of EGFR-TKI treatment.