联合纳洛酮综合治疗51例肝性脑病的疗效观察

Observation on effect of naloxone on 51 cases with hepatic encephalopathy

目的观察阿片类受体拮抗剂纳洛酮治疗肝性脑病的疗效。方法将51例肝性脑病患者,随机分成两组,两组均予去除诱因等综合治疗,治疗组加用纳洛酮。观察血清氨值的变化、神志转清醒时间及智力测验好转情况。结果治疗组较对照组能够明显降低患者的血氨水平(P<0.05),缩短肝性脑病昏迷患者的神志转清醒时间,同时提高了转清醒患者相关智力水平,治疗组有效率(84.6%)明显优于对照组(64%)。结论应用纳洛酮治疗肝性脑病近期疗效显著,远期疗效值得进一步研究。

Objective To observe the effect of naloxone in patients with hepatic encephalopathy（HE）.Methods 51 cases of HE were randomly divided into the treatment group consisted of 26 cases treated with naloxone and a complex treatment and the control group consisted of 25 cases only received a complex treatment.The therapeutic effect of naloxone was evaluated by observing the number of blood ammonia,the time from coma into a sober and the test of intelligence.Results The number of blood ammonia in the treatment group was lower than that in the control group,showing significant difference（P〈0.05）.Shorten the time from coma into a sober,and improved number connect test（NCT） and digit symbol test（DST） value.The total effective rate of the treatment group was 84.6% and that of control group was 64%,also showing significant difference（P〈0.05）.Conclusion For patients with hepatic encephalopathy,using naloxone can improve efficiency.It is value to the further studies for treatment of HE.