摘要
以2,4-二氟苯胺为原料,经溴化、Sandmeyer反应和格氏反应3步得到标题化合物,总产率约29%,纯度99.81%(GC法)。产物的结构通过MS及1HNMR验证。
2-Chloro-3,5-difluorophenol was synthesized from 2,4-difluoroaniline via bromination,the Sandmeyer reaction,the Grignard reaction,and esterification.The overall yield of the target product was 29% with its purity reaching 99.81%（by GC）.The structure of the product was confirmed by MS and 1HNMR.
出处
《化学试剂》
CAS
CSCD
北大核心
2010年第8期759-761,共3页
Chemical Reagents
关键词
2-氯-3
5-二氟苯酚
溴化
重氮化
格氏反应
合成
2-chloro-3
5-difluorophenol
bromination
Sandmeyer reaction
Grignard reaction
synthesis
