复元方对围手术期胃肠道肿瘤患者肠黏膜屏障功能的影响

Effect of Perioperative Treatment with Fuyuan(复元) Decoction on Intestinal Mucosal Permeability of Patients with Gastrointestinal Tumors

目的:探讨复元方对围手术期胃肠道肿瘤患者肠黏膜通透性的影响。方法:选取胃肠道恶性肿瘤并拟行手术者60例,随机分治疗组、对照组各30例。术前第3d起至术后第8d,治疗组加用复元方治疗,对照组则常规治疗。结果:两组术后第3d前白蛋白、纤维连接蛋白均较术前下降,c-反应蛋白、D-乳酸浓度均较术前升高(P>0.05)。术后第8d治疗组前白蛋白、纤维连接蛋白明显回升,c-反应蛋白、D-乳酸浓度下降,与对照组相比具有显著差异(P<0.05)。结论:围手术期应用复元方能改善胃肠道肿瘤患者肠黏膜通透性,保护肠黏膜屏障。

Objective To investigate the effect of perioperative treatment with Fuyuan（复元） decoction on intestinal mucosal permeability of the patients with gastrointestinal tumors. Methods Sixty patients with gastrointestinal tumors undergoing operation were randomly divided into treatment group and control group, 30 patients each. The patients in the treatment group received Fuyuan decoction plus routine treatment from the 3rd day before operation to the 8th day after operation, while the patients in the control group only received routine treatment. CRP, prealbumin, fibronectin albumin and D-lactic acid were determined before operation and on the 3rd and 8th day after operation. Results The levels of prealbumin, fibronectin albumin in both groups on the 3rd day after operation were less than those before operation without statistical significance （P〈0.05）, whereas the level of CP and D-lactic acid were more than those before operation without statistical significance （P〈0.05）. The levels of preabumin, fibronectin albumin in the treatment group rebounded on the 8th day after operation, while the level sof CRP and D-lactic acid was decline. There was significant difference between the two groups.（P〈0.05）. Conclusion Perioperative treatment with Fuyuan decoction culd improve the intestinal mucosal permeability of the patients with gastrointestinal tumors and protect the intestinal mucosal barrier.