左卡尼汀对血液透析患者营养状况及氧化应激的影响

Effects of Levocarnitine on Nutrition and Oxidative Stress Status in Maintenance Hemodialysis Patients

目的通过观察静脉注射左卡尼汀对维持性血液透析(maintenance hemodialysis,MHD)患者营养状态和氧化应激指标的影响。探讨左卡尼汀对MHD患者营养不良及氧化应激状态的治疗作用。方法选择透析龄超过3 m的MHD患者42例,每次透析结束后,静脉注射左卡尼汀1.0 g,进行为期3 m随访。结果 (1)左卡尼汀治疗3 m后,MHD患者的血白蛋白(P<0.05)和血红蛋白(P<0.01)较治疗前明显升高。血总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平治疗前后无显著差异。(2)MHD患者血浆MDA的平均值均较治疗前明显下降(P<0.01);SOD、GSHPx平均值较治疗前明显上升(P<0.01)。结论左卡尼汀可明显改善患者的营养状态.同时氧化应激状态明显好转。

Objective To investigate the effects of levocarnitine on nutrition and oxidative stress status in maintenance hemodialysis（MHD） patients.Methods Forty-two MHD patients were selected,who had undergone hemodialysis for at least three months before the study and were in a stable clinic status.One gram of 1evocarnitine was infused to the patients at the end of each dialysis treatment for three months.The parameters of nutrition and oxidative stress were evaluated.Results Treatment with levocarnitine for three months,the average serum levels of albumin（P0.05） and hemoglobin（P0.01） were elevated significantly.The average plasma levels of malondialdehyde（MDA） was significantly lower than those of baseline（P0.01）,however,the average plasma level of glutathione peroxidase（GSHPx） and superoxide dismutase（SOD） were elevated markedly（P0.01）.Difference was not significant between serum lipid parameters before and after the treatment.Conclusion Intravenous supplement with levocarnitine in MHD patients appears to be associated with an improvement of nutrition and oxidative stress status.