中国人群缺血性卒中及高血压候选基因的研究进展

Research progress of candidate genes of essential hypertension and Ischemic stroke in Chinese population

脑血管疾病为遗传因素和环境因素共同作用所致,其发病机制复杂。高血压、糖尿病、高血脂、肥胖等是脑卒中的危险因素。由于高血压病(EH)为其首要且独立的危险因素,近年来有关脑卒中侯选基因研究较多集中于与血压调节和高血压有关的基因。现将近年来在中国人群研究较多的一些基因及其多态性做一综述。

Cerebrovascular disease, which pathogenesis is perplexing, result from both genetic factors and environmental factors. Hypertension, diabetes, hypercholesterol and fat etc were the primary cause of stroke. Because essential hypertension （EH） is principal and absolute risk factor, the study about candidate genes of Ischemic stroke concentrate on genes of hypertension and pressure regulation recently. The paper was a summary for the candidate genes of essential hypertension and Ischemic stroke in Chinese population.