骨髓间充质干细胞移植治疗脑梗死及存在问题

Bone marrow-derived mesenchymal stem cells transplation for treatment of cerebral infarction and problems

骨髓间充质干细胞(BMSCs)已成为21世纪干细胞工程的热点和前沿,是最有前途的组织工程种子之一。大量的动物实验证实BMSCs移植治疗脑梗死能明显改善受损的神经功能,具有极大临床应用价值。但是在临床前期实验研究方面存在着众多的困惑性问题。本文就临床移植BMSCs移植治疗脑梗死及存在的问题做一综述。

In the 21 century Bone marrow-derived mesenchymal stem cells has become a hot spot and forward of the stem cell engineering, and is the most promising one of tissue engineering. A large number of animal experiments confirmed bone marrow mesenchymal stem cells transplantation for treatment of cerebral infarction can significantly improve the neurological fuction, with the great clinical value. However, in the prelinical research there are a growing number of confusing issues. In this review we will address clinical transplantion of bone marrow-derived mesenehymal stem cells for treatment of cerebral infraeiton and problems.