比索洛尔治疗37例急性心肌梗死后无症状性心肌缺血

Bisoprolol in the treatment of silent ischemia in patients with acute myocardial infarction

目的：观察比索洛尔对急性心肌梗死（ＡＭＩ）后无症状性心肌缺血的治疗作用。方法：用随机对照方法将７３例ＡＭＩ患者分为比索洛尔治疗组和对照组，采用２４小时动态心电图记录用药后无症状性心肌缺血发作情况，同时行核素心功能检查。结果：比索洛尔组缺血持续时间为１．５（０～２７．５）ｍｉｎ／２４ｈ，缺血总负荷为２．４（０～４６．５）ｍｉｎ／ｍｍ；对照组缺血时间为６．５（０～３９）ｍｉｎ／２４ｈ，缺血总负荷为１１．８（０～６９．６）ｍｉｎ·ｍｍ，两组比较，Ｐ＜０．０５。核素心功能检查比较两组差异无显著性。结论：比索洛尔能有效地治疗ＡＭＩ后无症状性心肌缺血。

Objective:To observe the effects of bisoprolol on the treatment of silent myocardial ischemia after acute myocardial infarction(AMI) Methods:73 patients with AMI were randomly divided into two groups(control and therapeutic) 24 hours of holter monitoring and nuclear cardiac function were measured in all patients Results:In the rapeutic group,total duration of silent isohemia was 1 5(0～27 5)min/24h,total ischemic burden was 2 4(0～46 5)min·mm/24h In control group,total duration of silent ischemic was 6 5(0～39)min/24h,total ischemic burden was 11 8(0～69 6)min·mm/24h Significant differences existed between the control and the placebo groap( P <0 05),Whife there was no difference on nuclear cardiac function between the two groups Conclusion:Bisoprolol significantly reduced the duation and total ischemic burden of silent ischemia in patients with AMI