厄贝沙坦对高血压合并高尿酸血症患者血尿酸代谢和左室功能的影响

Influence of irbesartan on serum uric acid and left ventricular function in hypertension incorporated with hyperuricacidemia metabolism patients

目的:观察并分析厄贝沙坦对轻、中度原发性高血压合并高尿酸血症患者血尿酸代谢和左室功能的影响,并与非洛地平比较。方法:72例轻、中度原发性高血压合并高尿酸血症患者随机、单盲分为两组,治疗组36例,用厄贝沙坦150 mg,口服,1次/d;对照组36例,用非洛地平5 mg,口服,1次/d,疗程均为8周。结果:8周末降压总有效率治疗组为81%,对照组为75%,两组间比较,P>0.05。血尿酸水平在8周末治疗组下降(-126±38)μmol/L(P<0.01),对照组下降(-25±32)μmol/L(P>0.05),两组间比较,P<0.01。左室功能指标在8周末治疗组IVST、LVPWT、LVMI明显降低(P<0.01),LVEF明显升高(P<0.01),IVST、LVPWT、LVMI、LVEF两组间比较,P<0.05。结论:厄贝沙坦不仅能有效降压,而且能降低血尿酸水平,改善左室功能。

Objective： To observe and analyze the influence of irbesartan in essential hypertension incorporated with hyperuricacidemia metabolism in the elderly patients and compare it with felodipine.Methods： 72 elderly patients with hypertension incorporated with hyperuricacidemia are divided randomly and averagely into irbesartan group（n=36） and felodipine group（n=36）,and treated by 150 mg irbesartan or 5 mg felodipine once per day respectively for 8 weeks.Results： The total effective rates of decompression were 81% for the irbesartan group and 75% for the felodipine group,respectively.There was no significant difference in curative effect between the two groups（P〉0.05）.Compared with pretreatment,the serum uric acid level was descented（-126±38）μmom/L（P〈0.01） in the irbesartan group and（-25±32）μmom/L（P〉0.05） in the felodipine group,there was significant difference between the two groups（P〈0.01）.After 8 weeks treatment,the IVST,LVPWT and LVMI of LV function descented while LVEF of LV function ascended apparently（P〈0.01）.There was significant difference between the two groups in IVST,LVPWT,LVMI and LVEF of LV function（P〈0.05）.Conclusion： Irbesartan can reduce BP and UA effectively as well as improve left ventricular function.