苦瓜总皂苷对2型糖尿病模型大鼠胰岛素抵抗、脂联素和瘦素的影响

Effects of Total Saponins from Balsam Pear on Insulin Resistance,Adiponectin and Leptin in Rat Model of Type 2 Diabetes

目的:方法:探讨苦瓜总皂苷对2型糖尿病模型大鼠血糖、胰岛素抵抗、脂联素和瘦素的影响。方法:采用高糖高脂加小剂量注射链脲佐菌素(streptozotocin,STZ)造2型糖尿病大鼠模型,通过测定各组血浆血糖、胰岛素、脂联素和瘦素水平,并且计算胰岛素敏感指数,来观察苦瓜总皂苷对2型糖尿病模型的影响。结果:各用药组可显著降低模型大鼠血浆血糖和胰岛素水平(P<0.01),显著升高胰岛素敏感指数(P<0.01),可升高血浆脂联素水平,降低血浆瘦素水平。结论:苦瓜总皂苷可改善胰岛素抵抗,有降糖的特点。

Objective： To explore the effect of total saponins from balsam pear（TSBP） on insulin resistance,adiponectin,leptin in rat model of type 2 diabetes.Method： The mice model of type 2 diabetes was established by eating food containing high sugar and fat and injected a samll dosage of streptozotocin（STZ）.The levels of FBG,FINS,adiponectin and leptin in blood plasma were measured,and ISI was calculated.Finally,the effect of TSBP in rat model of type 2 diabetes was evaluated.Result： Compared with control group,TSBP groups and diformin tablet group could significantly decrease the level of FBG and FINS（P 0.01）,and significantly rise ISI.TSBP groups could elevate the level of adiponectin,and decrease the level of leptin.Conclusion： TSBP can improve insulin resistance and has hypoglycemic action.