胸苷磷酸化酶在浸润性乳腺癌中的表达及其临床病理学意义

Expression of Thymidine Phosphorylase in Invasive Breast Carcinoma and Their Relation to outcome After the Treatment Based on 5-FU

目的:研究胸苷磷酸化酶(thymidine phosphorylase,TP)在浸润性乳腺癌中的表达及其临床病理学意义。方法:应用免疫组化法检测103例浸润性乳腺癌及24例乳腺良性病变中TP的表达情况。分析其在乳腺良恶性病变中的表达差异及其临床病理学意义。结果:浸润性乳腺癌组织中TP的表达明显高于正常组织,TP高表达组中淋巴结转移率明显高于TP低表达组。TP的表达与TNM临床分期、组织学分级呈正相关,而与患者年龄无关。结论:TP可作为浸润性乳腺癌判断预后的一个指标。

Objective：To detect the expression of thymidine phosphorylase in the advanced breast carcinoma and study the relationship between their expression and the prognosis.Methods：The expression of TP in 103 cases with advanced breast carcinoma and 24 cases with benign breast lesion was immunohistochemically assessed.Results：The expression of TP in malignant tissue are higher than that in benign tissue.The group with higher expression of TP has more possibility to appear lymph node metastasis.There is a positive association between the level of tumor TP expression and clinical stages,pathological grades and lymph node metastasis.Concluslons： The expression of TP can be as a efficacy index of predicting prognosis in patients of invasive breast carcinoma.