摘要
目的:考察不同微乳配方对左金微乳凝胶中有效成分经皮渗透的影响。方法:采用改良Franz扩散池,以凝胶中盐酸巴马汀、盐酸小檗碱、吴茱萸碱、吴茱萸次碱4种生物碱为评价指标,用HPLC方法测定接收液中上述4个成分含量。结果:不同微乳配方的左金凝胶中盐酸巴马汀、盐酸小檗碱、吴茱萸碱、吴茱萸次碱4种生物碱的经皮渗透速率和24h累积透过率有明显差异。结论:微乳处方的组成对药物的经皮渗透能力有一定的影响。
Objective：Investigated the effects of different prescription of microemulsion on transdermal permeability on Zuojin microemulsion based gel. Method：Improved Franz diffusion cell was adopted to research the transdermal permeability difference between these kinds of gels in mouse skin in vitro,and HPLC was used to determine the content of hydrochloride palmatine,berberine,evodiamine and rutaecarpine in receiving solution. Result：The permeation rate and 24 h accumulation transmittance of hydrochloride palmatine,berberine,evodiamine and rutaecarpine in different Zuojin microemulsion based gel were distinct. Conclusion：The transdermal permeability of drugs is influenced by the composition of microemulsion prescription.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第10期1-4,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金课题(30873444)
重大新药创制-中药研究关键技术(2009ZX09502-010)
重大新药创制-综合性中药新药研究开发技术大平台(2009ZX09301-005-05)
关键词
微乳凝胶
透皮
黄连
吴茱萸
microemulsionbased gel
transdermal
huanglian
rutaecarpine
