前列疏胶囊治疗前列腺炎药理学研究Ⅰ——对实验性细菌性前列腺炎大鼠模型的作用

Pharmacologicl Study on Action of Qianlieshu Capsule for Treating Prostatitis Ⅰ——Effect on Experimental Bacterial Prostatitis in Rat

目的:观察复方前列疏胶囊对实验性细菌性前列腺炎大鼠模型的影响。方法:采用前列腺腹叶注入大肠杆菌造模,观察前列疏胶囊不同剂量ig10d,对模型大鼠前列腺液白细胞数量、磷脂小体密度、细菌生长、前列腺质量、脏器指数以及病理组织学改变的影响。结果:前列疏胶囊可明显减少前列腺液白细胞数(P<0.01),抑制细菌菌落生长(P<0.01),高剂量组明显增加磷脂小体数(P<0.05),中、高剂量组前列腺质量下降(P<0.05,P<0.01),脏器指数降低(P<0.01)。前列疏胶囊对大鼠细菌性前列腺炎模型病理性炎症浸润有抵抗作用,并以高剂量组作用最强(P<0.05)。结论:前列疏胶囊具有较强的抗细菌性前列腺炎的作用。

Objective：To study the effect of Qianlieshu Capsule on bacterial prostatitis in rat. Method：The animal model of bacterial prostatitis was established by injection of Escherichia coli in ventral prostates,and Qianlieshu was given in different dosages for 10 days. The count of white blood cell,the density of lecithin,and bacteria colonies in prostatitis liquid,while the prostate weight,index,and pathological changes were observed. Result：Qianlieshu Capsule could obviously decrease white blood cells（ P〈 0. 01） and bacteria colonies（ P〈 0. 01）,and increased lecithin（P〈 0. 05） were only found for the high dosage,deduced prostate weight,index were observed in the middle and high dosages. The pathological of inflammmator changes were obviously inhibited in high dosage（P〈 0. 05）. Conclusion：Qianlieshu Capsule has significant anti-bacterial prostatitis actions.