中药注射剂致敏反应的研究进展

Advancement of Experimental Studies on Sensitization Reactions of Traditional Chinese medicine Injections

目的:探讨中药注射剂致敏反应实验研究概况,为中药注射剂的研究及应用提供思路。方法:概括归纳近年来国内外中药注射剂致敏性相关实验研究。结果:中药注射剂的过敏性抗原物质尚不明确,研究尚缺乏系统性,对致敏因素、致敏模型的研究还处于摸索阶段。结论:加强绿原酸及附加剂的抗原性研究,建立致敏动物模型,充分利用免疫化学和免疫芯片技术,为中药注射剂的开发和应用,提供新的研究思路。

Objective：To review the progress of sensitization reaction experiment research with Traditional Chinese medicine injections （TCMI）. Method：The experimental studies on sensitization reactions of TCMI were summed up. Result：The result shows that the studies lack systematicness. The researches on allergic sensitization factors and sensitization model are still in the stage of exploration. Conclusion：To provide new ideas,the research on chlorogenic acid and additives antigen should be strengthened,the animal models of allergen and the techniques of immune-chemistry and immune-chip should be fully utilized for the development and application of TCMI.