高血压患者红细胞镁含量、Mg^(2+)/Na^+交换速率的研究

Study of erythrocyte magnesium content and Mg2+/Na+ exchange rate in patients with hypertension

目的探讨原发性高血压（ＥＨ）、肾实质性高血压（ＲＨ）和肾血管性高血压（ＲＶＨ）患者红细胞镁含量（ＥＭＣ）、Ｍｇ２＋／Ｎａ＋交换速率（ＶＮＤｍａｘ）及其与血压的关系。方法原子吸收光谱火焰法。结果（１）ＥＨ组的ＥＭＣ［（２．０３±０．０６）ｍｍｏｌ／Ｌ］显著较正常对照组（２．１６±０．０４）、ＲＨ（２．１７±０．０５）和ＲＶＨ（２．１５±０．０４）组低，而ＶＮＤｍａｘ［（１５５．３±１５．２）μｍｏｌ·Ｌ－１·ｈ－１］显著较另外三组高（分别为９６．８±１３．２、９４．３±１４．２和９７．３±１２．５）。（２）ＥＨ组ＶＮＤｍａｘ与舒张压显著相关（ｒ＝０４８７２，Ｐ＜００５）。结论（１）ＥＨ患者ＶＮＤｍａｘ明显升高，是造成ＥＭＣ低下的原因，可能在疾病的发生发展中起一定作用。（２）ＲＨ、ＲＶＨ患者细胞镁代谢状况无异常。

Objective To investigate the erythrocyte magnesium content (EMC), magnesiumsodium exchange rate (VNDmax) and its relationship with blood pressure in patients with essential hypertension (EH), renal parenchymal hypertension(RH) and renal vascular hypertension(RVH). Methods EMC and VNDmax were measured by flame assay of atomic absorption spectrophotometry. Results (1) EMC in EH group 0.06)mmol/L] was significantly lower than normal control(2.160.04), RH(2.170.05) and RVH(2.150.04) group, while VNDmaxh-1]was significantly higher than other three groups (96.813.2, 94.314.2 and 97.312.5respectively). (2) VNDmax in EH group closely correlated to diastolic blood pressure (r=0.4872, P<005). Conclusion (1)VNDmax increases in EH,which is the cause of low EMC and might contribute to the pathogenesis of the disease. (2) cellular magnesium metabolism is not abnormal in RH and RVH.