摘要
目的：探讨钾离子通道开放剂对未成年兔心肌缺血再灌注损伤的保护作用。方法：在改良Ｌａｎｇｅｎｄｏｒｆ模型上，对Ｓｔ．Ｔｈｏｍａｓ液（Ｓ组）及用１０μｍｏｌ／ＬＮｉｃｏｒａｎｄｉｌ强化的Ｓｔ．Ｔｈｏｍａｓ液（Ｓ＋Ｎ组）两种停跳液进行低温缺血再灌注离体心脏实验。观察缺血前、后心功能变化（左心室变化压、左心室舒张末压、最大压力变化速率、心肌含水量及冠状动脉流量等指标）。结果：离体心脏缺血再灌注后，Ｓ＋Ｎ组左心室变化压、左心室舒张末压、最大压力变化速率及冠状动脉流量等指标方面恢复明显好于Ｓ组。结论：Ｎｉｃｏｒａｎｄｉｌ作为新的有效的停跳液成分，可增强Ｓｔ．Ｔｈｏｍａｓ对未成年兔心肌的保护作用。
Objective:The purpose of this study is to investigate the
effectiveness of Nicorandil,an opener of potassium channels in protecting myocardium of
immature rabbit hearts from ischemic reperfusion injury. Methods:On modified Landgendorff
apparatus,16 isolated hearts of 7 14 days immature rabbit were divided in two groups
randomly:St.Thomas' solution(group S)and St.Thomas' solution plus nicorandil(group S+N)and
subjected to 15°C hypothermia,2 hours of ischemia and 1 hour of reperfusion.The preischemia
and postischemia myocardial function were assessed by the percentage recovery of left
ventricle developed pressure(LVDP),left ventricle end diastolic pressure,±dp/dt max
,mycardial water content,and coronary blood effluent(CBE). Results:Postischemic recovery of
LVDP,left ventricular end diastolic pressure(LVEDP),±dp/dt max ,and CBE were significantly
better in group S+N than in groups. Conclusion:As an new and effective
composition,nicorandil can improve significantly the myocardial protective effect of the
St.Thomas solution for immature rabbit hearts.
出处
《中国循环杂志》
CSCD
北大核心
1999年第2期118-120,共3页
Chinese Circulation Journal
