乌贝消疣颗粒治疗幽门螺杆菌相关性疣状胃炎120例临床观察

Effect of Wubei Xiaoyou Granules on the Helicobacter Pylori-related Verrucous Gastritis—A Clinical Observation on 120 Cases

目的观察乌贝消疣颗粒治疗幽门螺杆菌相关性疣状胃炎的临床疗效。方法将符合病例入选标准的240例患者随机分为治疗组和对照组,每组各120例。治疗组用乌贝消疣颗粒治疗,每次1袋,每日3次,口服,4周为1个疗程;对照组口服奥美拉唑20mg,每日2次,连用4周,阿莫西林1000mg,每日2次,克拉霉素500mg,每日2次,连用1周。观察症状改善情况、疣状结节数目及Hp阴转情况。结果乌贝消疣颗粒治疗幽门螺杆菌相关性疣状胃炎Hp转阴率与对照组比较无统计学意义(P>0.05),对单次症状改善及疣状结节数目减少均优于对照组(P<0.05或P<0.01)。结论乌贝消疣颗粒治疗幽门螺杆菌相关性胃炎临床疗效确切可靠。

Objective To study the clinical effect of Wubei Xiaoyou Granules （Granules of Dark Plum and Fritillary Bulb for Ver ruca） on the Helicobacter pylori-related verrucous gastritis. Methods Totally 240 patients conformed to the inclusion criteria were randomized into treatment group and control group. The former was treated with Wubei Xiaoyou Granules, oral administration, one package each time, three times each day, for 4 weeks; while the latter was given Omeprazole tablets 20mg, twice each day, for 4 weeks, amoxicillin 1 000mg, twice each day, and clarithromycin 500mg, twice each day, for 1 week. The improvement of symptoms, number of verrucous nodules and rate of HP transferring to negative were observed. Results There was no statistical significance between the treatment group and control group in the rate of HP transferring to negative （P〉0.05）, but the treatment group was better than the control group in symptom improvement and reduction of number of verrueous nodules（P〈0.01）. Conclusion Wubei Xiaoyou Granules is effective for the helicobaeter pylori-related verrucous gastritis.