烟酸缓释片的制备及溶出度的测定

Preparation of the Nicotinic Acid Sustained Release Tablet and Determination of Dissolution rate

制备烟酸缓释片剂，并评价其体外释放特性。根据中国药典１９９５年版所载的溶出度测定方法测定其释放度，并建立紫外分光光度法测定含量。烟酸缓释片体外释放符合Ｈｉｇｕｃｈｉ模型。样品在１０００ｍｌ０．１ｍｏｌ／Ｌ盐酸中用转蓝法（５０ｒ／ｍｉｎ）测得２、４、６ｈ的释药量分别达到４４．１２％、６９．９７％和８４．９５％。Ｔｄ为３．９７ｈ。该片剂处方较为合理，适合于工业化生产。

Nicotinic acid sustained release tablet was prepared and its releasing features in vitro were evaluated. Dissolution rate of the drug was determined by the method from China Pharmacopocia in 1995. A new method (UV) was established for determining the concentration of nicotinic acid. Release in vitro of the drug accorded with Higuchi model. Accumulative release amount of the drug in 1000 ml of 0.1 mol/L hydrochlorid acid at 50 r/min was 44.12 %, 69.97 % and 84.95 % respectively at 2, 4, 6 h. Td=3.97 h.