复发妇科恶性肿瘤患者HIF-1α、EGFR的表达及其与放射敏感性的关系

The expressions of HIF-1α and EGFR in patients with recurrent gynecologic malignancies and their relationship with radiosensitivity

目的探讨复发妇科恶性肿瘤患者HIF-1α、EGFR的表达及其与放射敏感性的关系。方法采用免疫组化的方法检测了32例复发妇科恶性肿瘤患者初次手术后及二次复发灶切除术后肿瘤组织的HIF-1α及EGFR表达水平。所有患者二次手术前均经放疗。32例二次手术中有15例行腹腔镜下病灶切除及125I粒子植入,17例行开腹手术切除。结果第二次手术后肿瘤组织的HIF-1α及EGFR的阳性表达率略高于初次手术组,但无统计学意义(P>0.05)。第二次手术后肿瘤组织的HIF-1α及EGFR的强阳性表达率明显高于初次手术组(P<0.05)。10例HIF-1α及EGFR呈强阳性表达的患者预后很差。结论 HIF-1α及EGFR表达增加可降低肿瘤放射敏感性,HIF-1α及EGFR强阳性表达可作为预测放疗或125I粒子植入的疗效的指标。

Objective：To investigate the expressions of HIF-1α and EGFR in patients with recurrent gynecologic malignancies and their relationship with radiosensitivity.Methods：The expressions of HIF-1α and EGFR were examined by means of immunohistochemistry in 32 cases of tumor tissues after initial operation and secondary operation.Radiotherapy was used in all patients before the secondary operation.of total patients with the secondary operation,laparoscopic srugery and 125I seeds implantation were used in 15 patients and laparotomy were used in the others.Results：The positive expression rate of HIF-1α and EGFR of the tumor tissues after the secondary operation were a little higher then those after the initial operation,but the difference had no statistical significance（P 〉0.05）.The strong positive expression rate of HIF-1α and EGFR of tumor tissues after the secondary operation were significantly higher than those after the initial operation（P 〈0.05）.10 patients with strong positive expression experienced bad prognosis.Conclusions：lncreased expression of HIF-1α and EGFR can decreased the radiosensitivity.The strong positive expression of HIF-1α and EGFR could be a helpful marker to predict the therapeutic efficacy for radiotherapy and 125I seeds implantation.