宁波地区1220例孕妇TORCH感染状况分析

The analysis of 1220 pregnant woman's TORCH in Ningbo

目的了解宁波地区孕妇TORCH感染状况,为预防TORCH感染、降低新生儿出生缺陷发生率提供参考资料。方法采用酶联免疫吸附试验(ELISA)对1220例妊娠妇女进行TORCH-IgM及IgG抗体检测,然后采用病例-对照研究分析TORCH感染与不良妊娠的相关性。结果 TORCH的10项检测结果 ,包括TOX、RUV、CMV、HSV-Ⅰ和HSV-Ⅱ的IgM阳性率分别为2.42%,1.89%,4.26%,9.19%,2.54%,IgG阳性率分别为3.01%,65.4%,90.47%,52.86%,13.3%。本地区不良妊娠孕妇群体中TOX、RUV、CMV、HSV-Ⅰ和HSV-Ⅱ的IgM抗体阳性率分别为12.77%,10.20%,14.29%,21.28%,10.64%与对照组比较差异性显著(P<0.01)。结论宁波地区妊娠妇女HSV-Ⅰ感染率最高,其次是CMV。TORCH感染是不良妊娠结局的重要危险因素,应重视TORCH病原体感染的早期筛查和诊治。

Objective：To investigate the condition of TORCH infection in pregnant women in Ningbo and provide guidance to reduce birth defect rates by preventing TORCH infection.Methods：Serum samples from 1220 pregnant were tested for TORCH-IgM and TORCH-IgG by the enzyme linked immunosorbent assay（ELISA）,and the relationship between TORCH infection and abnormal pregnancy history was analyzed by case-control study.Results：The IgM positive rates of TOX,RUV,CMV,HSV-Ⅰ and HSV-Ⅱwere respectively 2.42%,1.89%,4.26%,9.19% and 2.54%.The IgG positive rates of TOX,RUV,CMV,HSV-Ⅰand HSV-Ⅱwere respectively 3.01%,65.4%,90.47%,52.86% and 13.3%.The positive rates of IgM antibody which indicated TOX,RV,CMV,HSV-Ⅰ and HSV-Ⅱ infection of local women population with abnormal pregnant history were 12.77%,10.20%,14.29%,21.28% and 10.64%,respectively,and were significantly higher than that of control group（P〈 0.01）.Conclusion：In this investigation,the infection rates of HSV-Ⅰ was the highest in pregnant women in Ningbo,and CMV＇s was the second.TORCH infections were important risk factors responsible for abnormal pregnant outcomes of pregnant women and more attention should be paid to the early screening,diagnosis and treatment of TORCH infection.