雄激素受体在膀胱尿路上皮癌中的表达及其临床意义

Expression of androgen receptor in bladder urothelial carcinoma and its clinical significance

目的 观察雄激素受体（AR）在膀胱癌中的表达及其与临床病理特征的关系,探讨其临床意义.方法 采用免疫组织化学SP法检测AR蛋白在123例膀胱尿路上皮癌和18例正常膀胱黏膜中的表达.结果 AR蛋白的阳性表达主要定位于细胞核中,其在膀胱癌组织中阳性表达率为46.3%,在正常膀胱黏膜组织阳性表达率为5.6%,差异有统计学意义（P＜0.05）.AR的表达率随着膀胱癌病理分级和临床分期的升高而增高（P＜0.05）,而与年龄和性别无明显相关（P＞0.05）,有淋巴结转移者AR表达率也显著升高（P＜0.05）.结论 AR在膀胱癌组织中有广泛表达,且与膀胱癌的分化和浸润性进展密切相关,提示AR蛋白可能在膀胱癌的发生发展中起重要作用.

Objective To investigate the expression of androgen receptor （AR） in bladder urothelial carcinoma and to explore its clinical significance. Methods Immunohistochemical SP method was employed to detected the expression of AR in bladder cancer tissue （123 cases） and the normal controls （18 cases） . In addition,clinicopathological data of them were analyzed. Results AR protein was mainly localized at cellular nucleus of malignant cells. The positive expression rate of AR in bladder cancer tissue was 46.3% ,but low positive expression rate （5.6% ） was found in normal bladder tissue. The expression of AR was markedly associated with tumor pathological grade and clinical stage （ P 〈 0.05 ） , but not with age and sex. Moreover,the expression of AR was observed more frequently in cases with lymph node metastasis. Conclusion The expression of AR is associated with differentiation and invasion in bladder urothelial carcinoma, it implies that AR might play important roles in the development and progression of bladder cancer.