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非小细胞肺癌中DLEC1的表达缺失与临床病理因素的相关研究 被引量：5

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摘要 目的:探讨DLEC1蛋白在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法:应用免疫组织化学Elivision法检测83例NSCLC及83例相应癌旁组织中DLEC1的表达,分析在不同临床病理指标下DLEC1蛋白的表达情况。结果:NSCLC组织中DLEC1蛋白的失表达率为74.70%(62/83),显著高于癌旁组织中的失表达率32.53%(27/83)(P<0.05)。DLEC1的表达与NSCLC组织学类型、淋巴结转移及TNM临床分期密切相关(P<0.05),但与患者的年龄、性别、肿块大小、分化程度无关(P>0.05)。结论:DLEC1在非小细胞肺癌中失表达,可能对NSCLC的发生发展起着一定的作用。
作者 刘艳华 罗达亚 艾有生 刘勇 熊小亮
机构地区 南昌大学医学院 江西省第一人民医院
出处 《实用医学杂志》 CAS 北大核心 2010年第16期2898-2901,共4页 The Journal of Practical Medicine
关键词 癌 非小细胞肺 DLEC1 免疫组化
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献11

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共引文献10

同被引文献49

  • 1安曙光,汪超,丁刚,蒋向阳.肺癌患者血清C反应蛋白测定的临床意义[J].安徽医学,2005,26(3):180-181. 被引量：8
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  • 3任秀红,董文川,刘平平.晚期非小细胞肺癌患者CRP与肿瘤标记物的对比分析[J].华南国防医学杂志,2005,19(5):14-16. 被引量：7
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  • 5赵怡卓,张伟,吴京,韩宝惠.肺癌患者血清C反应蛋白检测与预后关系的探讨[J].临床肿瘤学杂志,2007,12(8):575-578. 被引量：20
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引证文献5

二级引证文献14

实用医学杂志
2010年 第16期

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