532nm多脉冲光辐照人活体皮肤黑色素的热响应

Thermal Responses of Human Skin Melanin In Vivo to 532 nm Multi-Pulse Laser

脉冲光与皮肤组织的选择性光热解效应(Selective photothermolysis)在皮肤病损激光治疗中具有广泛应用。在相同参数光辐照下,个体皮肤温度场分布差异主要源于表皮黑色素含量不同。针对皮肤表皮黑色素含量差异,实验研究了532nm多脉冲光与不同个体黄色人种皮肤黑色素的热响应。提出了在无损光剂量辐照下基于脉冲光热辐射度量术(PPTR)确定黄色人种个体皮肤表皮光学吸收系数的方法,并比较了不同参数光辐照下皮肤热响应的数值模拟和实验结果。研究结果表明皮肤热响应的数值模拟和实验结果具有较好的一致性,因而这一方法对于优化选择个体皮肤光治疗辐照参数具有重要意义。

The selective photothermolysis,induced by the interaction of pulsed laser and skin,has been widely used in laser medicine.The melanin content is mainly responsible for the surface temperature discrepancy in the individual skin irradiated by pulsed laser with the same parameters.The thermal responses of individual Asian skin melanin in vivo to 532 nm pulsed laser are experimentally studied.A method to ascertain the optical absorption coefficient of individual Asian skin epidermis is presented based on the pulsed photothermal radiometry,and the simulated and experimental surface temperatures of individual skin are compared.The results show that the simulated and experimental surface temperatures of individual skin are consistent,and the method presented is of significance for optimizing light treatment parameters of individual Asian skin lesion.