布拉氏酵母菌预防婴幼儿抗生素相关性腹泻临床研究

Prevention of antibiotic-associated diarrhea by boulardii in children

目的:探讨布拉氏酵母菌对婴幼儿期下呼吸道感染患儿抗生素应用中腹泻的预防作用。方法:216例应用抗生素治疗的下呼吸道感染患儿随机分成两组,一组114例(预防组)同时服用布拉氏酵母菌,另一组102例(对照组)开始不用任何微生态制剂,出现腹泻后加服布拉氏酵母菌,比较两组腹泻的发生率,疗效,腹泻持续时间以及腹泻疗程并进行统计分析。结果:预防组继发腹泻22例,发病率19.29%;对照组腹泻39例,发病率为38.24%。预防组患儿腹泻持续时间(3.14±0.86)d,对照组患儿腹泻持续时间(4.58±0.91)d;预防组腹泻疗程(4.09±1.11)d,对照组腹泻疗程(6.47±1.10)d,两组腹泻持续时间、腹泻疗程比较差异有统计学意义(t=6.06,8.16,P均<0.01)。结论:布拉氏酵母菌能降低婴幼儿期下呼吸道感染患儿抗生素应用中腹泻的发病率,早期应用可缩短腹泻持续时间和疗程,利于患儿康复。

Objectives： To investigate the prevention of antibiotic-associated diarrhea by boulardii in children.Methods： In a randomized trial,216 children were enrolled,and divided into 2 groups.Boulardii was administered to 114 children who received antibiotic therapy before diarrhea（prevention）;or to other 102 children after diarrhea（control）.The incidence of AAD in two groups was compared.Results： The incidence of diarrhea was 19.29% in prevention group and 38.24% in the control group.The mean duration of diarrhea was（3.14±0.86） d in prevention group and（4.58±0.91） d in control group.The treatment of 2 groups were（4.09±1.11） d and（6.47±1.10） d.There were significant difference between two groups in both indicators（P〈0.01）.Conclusion： Boulardii can be used to prevent antibiotic-associated diarrhea in children.