神经节苷脂治疗手足口病并发病毒性脑炎的临床研究

Ganglioside Treatment of HFMD and Clinical Study of Vviral Encephalitis

目的探讨神经节苷脂治疗手足口病并病毒性脑炎对患儿神经系统的影响。方法对102例患儿随机分成2组,治疗组52例在常规治疗的基础上给予神经节苷脂(齐鲁制药厂)20mg加入10%葡萄糖溶液50～100ml中静脉注射,总疗程为5～7d。对照组于常规治疗的基础上加用胞二磷胆碱(山东新华制药厂)0.125～0.25g/d,5～7d。结果两组显效率及总有效率相比较均有统计学意义(P<0.05)。结论神经节苷脂治疗小儿手足口病并发病毒性脑炎在退热、止惊、神志转清等方面疗效优于对照组,较快的控制了脑炎的临床症状,明显减少后遗症发生率。

Objective To investigate the treatment of hand,foot and mouth disease and ganglioside viral effects on the nervous system in children.Methods Totally 102 patients were randomly divided into 2 groups,52 patients on the basis of conventional therapy for ganglioside 20 mg 10% glucose solution by adding 50～100 ml of intravenous injection,the total treatment usually 5～7d.Control group based on conventional therapy use citicoline,0.125～0.25g/d,5～7d.Results There was efficient and total effective rate compared,there were significant differences（P0.05）.Conclusion Ganglioside treatment of children with hand,foot and mouth disease and viral encephalitis in the fever,only scared of consciousness such as more effective than the control group,the fast control of the clinical symptoms of encephalitis,significantly reduced the inccidence of sequelae.