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复合万古霉素海藻酸钠/壳聚糖缓释载体的体外释放研究 被引量：1

Drug Releasing Test In Vitro of Sodium Alginate/Chitosan Incorporated With Vancomycin as Drug Delivery System
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摘要 目的探讨复合万古霉素海藻酸钠/壳聚糖(VCM/ACA)缓释系统中万古霉素缓释的动力学规律及影响因素。方法将万古霉素与海藻酸钠质量比分别为5:6和1:1的载体进行冷冻干燥处理和未冷冻干燥处理后制备成4组VCM/ACA载药载体。将载药载体放入pH7.2模拟体液PBS液中浸泡,通过测定浸泡液中万古霉素浓度,观察药物缓释的动力学规律和影响因素。结果 VCM/ACA载药载体的药物释放速度和释放量受载药量、调和比和冷冻干燥处理条件的影响。经冷冻干燥处理后调和比为1:1的载药载体可缓慢释药达250h以上。结论经过冷冻干燥处理万古霉素与海藻酸钠质量比(VCM:ALG)为1:1的载药载体体外能够稳定缓释万古霉素,可以满足临床实际需要。 【Objective】To investigate the delayed releasing profile and different factors effected in vitro in course of Sodium Alginate/Chitosan incorporated with Vancomycin（VCM/ACA） releasing.【Methods】The VCM /ACA implants were divided into 4 groups depending on ratio of power to mixing solution（VCM：ALG = 5：6 or 1：1）,with or without freezing and drying.Then each group of VCM /ACA implants were putting in bottle dipping and to observe the releasing characteristic.【Results】VCM/ACA implants can last more than 250.1 hours.The releasing characteristic dependented on drug amount,mixing solution volme and the management.【Conclusion】The VCM/ACA（1：1） implants under the management of freezing and drying has remarkable relseasing profile,can use to satisfy the need of clinical.
作者 李瑞欣 马小军 王卫明 李诗荟 王为 赵德伟 郭林 于晓光
机构地区 大连大学附属中山医院 中国科学院大连化学物理研究所
出处 《中国医学工程》 2010年第2期5-9,14,共6页 China Medical Engineering
基金 大连市科技局青年基金(2004B3SF157) 大连市科技局复合人才基金(2008J21JH001)资助 辽宁省自然科学基金(20062135)
关键词 海藻酸钠/壳聚糖 万古霉素 药物缓释系统 体外实验 Sodium alginate/chitosan Vancomycin Drug delivery system In vitro
分类号 R965.1 [医药卫生—药理学]
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参考文献15

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中国医学工程
2010年 第2期

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