血清胱抑素C对重型颅脑损伤继发肾功能改变的应用价值

Studies on the serum Cystatin C concentration as a marker of renal function in patients with severe craniocerebral trauma

目的探讨血清胱抑素C(Cys-C)在重型颅脑损伤继发肾功能改变中的意义。方法采用胶乳增强免疫透射比浊法测定43例重型颅脑损伤患者与36例健康者的Cys-C含量,进行比较分析。结果与健康对照组比较,颅脑损伤组血清Cys-C浓度明显升高(P<0.01),异常百分率差异显著(P<0.01),且较尿素氮和血肌酐有更高的异常检出率(P<0.05)。结论胱抑素C可作为重型颅脑损伤合并继发肾功能损伤早期诊断的首选指标。

Objective To investigate the serum cystatin C concentration as a marker of renal function in patients with severe eranioeerebral trauma. Methods The serum cystatin C concentration of 43 patients with severe craniocerebral trauma and 36 healthy subjects were determined by latex particle intensified turbidimetric immunoassay method. Results Serum cystatin C concentrations were higher in group with severe craniocerebral trauma than that in healthy group（P〈0.01） ,there was significant difference in the percentage of increase serum cystatin C concentrations（P〈0.01） ,and the positive rate of serum cystatin C was higher than which of BUN and Scr（P〈0.05）. Conclusion Serum cystatin C determination could be a valuable tool in patients with severe craniocerebral trauma for early diagnosis of impaired renal function.