老年糖尿病患者血清sIL—2R水平和T细胞亚群的变化

The Serum level of sIL-2R and the changes of T-lymphocyte Subsets in Elderly Type 2 diabetes mellitus.

分别采用抗体致敏的红细胞花环法和双抗体夹心法对70例老年2型糖尿病患者血T细胞亚群和可溶性白介素2受体(sIL-2R)进行了测定.发现患者T细胞亚群,CD4、CD4/CD8明显降低、CD8明显升高,与对照组比较P<0.01.而sIL-2R水平与对照组比较P<0.01且与T细胞亚群CD4、CD4/CD8成负相关,与CD8成正相关;同时显示以上改变与2型糖尿病患者的病情轻重有关.病情控制不满意者其改变更为显著.

The double antibody sandwich and antibody sensitire rosette formation test were used to determine the sIL-2R and T-lymphocyte subsets in 70 cases of type 2 diabetes mellitus patients in the elderly. The result showed that T-lymphocytes subsets CD4 and the ratio of the group (Type 2 diabetes mellitus) were lower than the control group significantly (P<0. 01),the count of CDS was higher obviously. Level of slL-2R serum was significantly higher in Type 2 diabetes mellitus than that in the control(.P<0. 01) ,sIL-2R in serum was negatively correlated to the count of CD4 and ratio of CD4/CD8,Positively correlated to the count of CD8. This changes was related with type 2 diabetes mellitus activation. Expectly fail to cure.