小承气汤等三方泻下作用差异物质基础研究

Preliminary Study on Material Basis of Different Laxative Potency of Xiao Chengqi-Tang and Other Two Prescriptions

结合药理和化学方法对小承气汤、厚朴大黄汤及厚朴三物汤三方泻下作用物质基础进行初步研究。药理研究结果显示：三方均明显增加小鼠大肠湿重．其泻下作用强度与所含大黄成正比，小承气汤效价最高；其拆方研究表明．影响泻下作用的最显著因素为大黄，次显著因素为枳实。三方化学成分研究结果显示：小承气汤中结合蒽醌含量最高。表明三方均具有明显泻下作用，其效价差异的物质基础与方中所含大黄及其煎出的结合蒽醌含量有关。

In this paper. prelminary study on material basis of different laxative potency of Xiao Chengqi -Tang. Houpo Dahuang-Tang and Houpo Sanwu - Tang was performed by pharmcological and chemical methods. Pharmacologlcal experirnents showed that these three complex prescriptions an increased wet weight of large intestine of mice and the purgative potency was in direct proportion to the content of Dahuang. Xiao Chengqi -Tang had the strongest action, Dahuang was the most significant active factor. In chemical research. content of total and free anthraquinone were determined by HPLC. The results showed that content of combined anthraquinone were the highest in Xiao Chengqi-Tang, while content of total and free anthraquinone were the highest in Houpo Dahuang-Tang. To sum up - such three complex prescriptions had purgative action with different potency.their material basis may be their different content of combined anthraquinone.