异丙酚辅助硬膜外麻醉用于卵巢癌根治术

Propofol an Adjuvant for Epidural Anesthesia in Radical Operation of Ovary Cancer

目的异丙酚辅助硬膜外麻醉用于卵巢癌根治术，观察术中血液动力学的变化及麻醉镇静的深度，并与哌替啶、异丙嗪辅助硬膜外麻醉的效果相比较。方法50例行卵巢癌根治术的病人，随机分为两组，Ⅰ组异丙酚组25例，Ⅱ组哌替啶组25例，Ⅰ组切皮前静脉给异丙酚负荷剂量1mp·kg-1，然后再以50μg·kg－1·min-1的速度静脉连续输注异丙酚，见组在切皮前静脉注射哌啶1mg·kg－1，异丙嗪0．5mg·kg－1。结果平均动脉压Ⅰ组于用药后10min内低于基础水平，有显著性差异，Ⅱ组无明显改变；心率Ⅰ组无明显改变，Ⅱ组明显增快，有显著性差异。镇静的效果以Ⅰ组为好。结论异丙酚辅助硬膜外麻醉可安全用于卵巢癌根治术，较哌异合剂好。

Objective This study was concerned about the cardiopulmonary effect and sedation effect of propofol as an adjuvant for epidural anesthesia in radical operation of ovary cancer .Method Fifty patients were randomly divided into two groups,undergoing epidural anesthesia .Group Ⅰreceived propofol 1 propofol 1 mg·kg-1 in bolus , followed by 50 μg·kg-1.min -1 infusion for maintenance. GroupⅡreceived dolantin l mg·kg-1 and phernegan 0. 5 mg·kg-1 for intravenous injection. MAP, HR and sedation were monitored during the course. Result The level of MAP significantly decreased in GroupI in the first ten minutes. The HR significantly increased in groupⅡ. Group Ⅰ had better sedation effect for GrouP Ⅱ.Conchusion It's suggested that infusion of propofol 50μg·kg- 1 ·min -1 for maintenance after 1 mg·kg-1 in bolus as an adjuvant for epidural anesthesia in radical operatin of ovary cancer be applicable.[