食管鳞癌间质中多核巨噬细胞浸润与预后的关系

Relation Between Multinuclear Macrophage Infiltration lion in the Stroma of Esophageal Squamous Cell Carcinoma and Prognosis of the Disease

目的探讨多核巨噬细胞浸润与食管癌的关系及其临床意义。方法观察90例生存5年以上和95例死于1年内的食管鳞癌间质中多核巨噬细胞，淋巴细胞浸润、肿瘤分化、胶原纤维增生、淋巴结内癌转移。结果癌间质中多核巨噬细胞浸润阳性在生存5年组明显高于1年内死亡组（P＜0．01）。肿瘤间质淋巴细胞浸润，淋巴结内癌转移，同时有多核巨噬细胞出现在生存5年以上组亦多于1年内死亡组。结论食管鳞癌间质内多核巨噬细胞浸润是宿主抗肿瘤的重要免疫形态学表现，可作为衡量预后的指标之一。

Objective To study the relationship between the infiltraion of multinuclear macrophage and the incidence of esophageal carcinoma .Methods The oberservations of the cases of multinuclear macrophage, lymphocytes infiltaion, tumor differentiation, collagen fibrous hyperplasia and intralymphadenmetastasis were made in the stroma of esophageal squamous cell carcinoma from 2 groups of patients (GrouP 1 composed of 90 cases who survived for over 5 yeare,GrouP 11 comas of 95 cases who died within one year). Results The results showed that the positive reaction of the multinuclear macrophage infiltration in the cancer stroma in Group 1 was apparently more than those showed in gooup 11 (P < 0.01 ) .The lymphocytic infilration and intralymphadenmetastasis , in company with multinuclear macrophages in GrouP 1 are more than those in Group 11. Conchusions It is suggested that the multinuclear macrophage infiltion is an important expression ofhost immunologic defence against cancer and can be taken as one of the measurements for the prognosis of the disease.[